2015 Volume 3 Issue 2 Pages 177-182
Living kidney donors (LKDs) are known to increase their blood pressure (BP) by decreased renal functions after donation. The effects of kidney donation on BP and several vascular parameters among LKDs are of great interest. However, there is little evidence about them. The objective of this study was to clarify the effect of kidney donation on BP and several vascular parameters among LKDs. We chose LKDs who had measured 24-hour ambulatory blood pressure monitoring (ABPM) before and one year after kidney donation in our institution between November 2008 and March 2013. We assessed mean 24-hour BP, the pattern of nocturnal BP, and vascular parameters; brachial-ankle pulse wave velocity (baPWV), cardio ankle vascular index (CAVI), flow mediated dilation (FMD), and augmentation index (AI). During the observation period, 62 donated a kidney in our kidney center, of which 27 were measured ABPM both before and one year after kidney donation. After donation, LKDs had no change in ABPM pressure (pre 122±15/75±9 vs. post 121±12/75±8mmHg) and vascular parameters such as baPWV, CAVI and FMD. Whereas, AI which is related to the central artery blood pressure, was significantly elevated (pre 8.7±15.1 vs. post 17.9±15.7%). Although blood pressure can be well controlled by appropriate interventions even after kidney donation, the augmentation index is elevated at that time. AI would be useful in detecting early CVD marker among LKDs.
