2015 Volume 3 Issue 2 Pages 189-194
【Background】The lack of donors is a serious problem around the world. Definition of Expanded Criteria Donor (ECD) has been accepted and is being applied for kidney transplantation in Europe and North America. However, definition of ECD for deceased donor kidney transplantation has not been developed yet in Japan.【Patients and methods】We analyzed data of 1,051 recipients who received deceased donor kidney transplantation in East Japan. Based on kidney function one year after transplantation, we divided the recipients into the standard groups (Cr＜2.0mg/dL, n＝802) and the poor groups (Cr≧2.0mg/dL, n＝220). We examined the graft survival and analyzed relevant risk factors.【Results】The renal graft survival rates were significantly worse in the poor groups than in the standard group ten years after transplantation (87.9％ vs. 47.2％, P＜0.0001). Significant donor risk factors for graft failure were age, donation after circulatory death, a history of high blood pressure, presence of cerebrovascular disease, average urine flow and blood pressure just before kidney procurement, TIT and WIT. The significant recipient risk factors were gender (male) and the length of time on dialysis prior to renal transplantation.【Conclusion】There is a need for developing definition of ECD for deceased donor kidney transplantation in Japan. To develop ECD we should thoroughly analyze factors influencing renal graft function.
