Post-Transplant Diabetes Mellitus (PTDM)

Abstract

Although recent advances of immunosuppressive therapy have brought about good results for renal transplantation, death with functioning graft is becoming of major concern. Post-transplant diabetes mellitus (PTDM) is a risk factor for cardiovascular attack that influences the outcome after transplantation. In order to prevent the development of PTDM, it is important to evaluate the risk preoperatively, to perform a periodic examination postoperatively and to treat properly at an early stage. Immunosuppressive drugs should work to prevent rejection, but have become one of the major causes of PTDM. There are currently several anti-diabetic medicines available. However, improvement of lifestyle and the treatment of obesity are more important than medication. Severe hypoglycemia must be prevented to avoid the onset of cardiovascular attack. Therefore, it is necessary for a transplant surgeon to collaborate with the staff to treat diabetic patients.