2016 Volume 4 Issue 1 Pages 92-98
Naïve human tends to produce non-self HLA antibody as a result of blood transfusion, pregnancy/labor, previous organ or tissue transplant. If the preformed anti-HLA antibody were specific (DSA), acute antibody mediated rejection (AMR) could be taken place highly after allogeneic organ transplant without desensitization methods. Thus, the kidney transplant for recipients who posses DSA had been prudent for a while. Recently, the thorough understanding of AMR, progression of antibody detection tool such as the developing of solid phase assay, sophisticated desensitization protocol including B cell depleting agents, therapeutic apheresis targeting removal and suppression of production of DSA has been enabled to perform kidney transplant relatively safely. We, herein introduce the desensitization methods and the outcome in our institution.
