2016 Volume 4 Issue 1 Pages 99-106
【Background】Pregnant women with renal allografts often face several complications such as chronic deterioration of graft function and increased risk of preterm delivery. We examined women with renal transplants who became pregnant and delivered at our hospital.【Methods】Of 36 women who underwent renal transplantation and became pregnant and delivered at Osaka University Hospital between 1977 and 2014, 28 women with complete data served as subjects.【Results】Mean recipient age at the time of transplantation was 27.4 (19 ～ 38) years. Mean duration from transplantation to delivery was 5.9 years. The 28 recipients became pregnant a total of 40 times after renal transplantation, and neonates were delivered in 32 of the 40 pregnancies. Four recipients delivered twice and 2 recipients delivered twins. As a result, 34 neonates were delivered. Mean gestational period was 36.3 (27 ～ 41) weeks, and mean birth weight was 2,423 (724 ～ 3,544)g. Intrauterine growth retardation was observed in 3. One child was born with a double-outlet right ventricle and another child had congenital unilateral hydronephrosis. In 7 of the 32 deliveries (22%), renal function worsened after delivery. Rates of graft survival for the 28 recipients at 1, 5 and 10 years after delivery were 100%, 86% and 74%, respectively. Prognosis for renal transplantation was significantly poorer for recipients with hypertension prior to pregnancy than for recipients without hypertension (log-rank test, p=0.0008).【Conclusions】Rates of graft survival after delivery were mostly favorable. In patients with drug-treated hypertension prior to pregnancy, subsequent renal function may be adversely affected.
