The clinical outcome of kidney transplantation of fifty years in Nagasaki University

Abstract

【Purpose】At Nagasaki University we underwent the first case of kidney transplantation in 1965. During the approximately 50 years until 2015, we carried out renal transplant of 226 cases. Herein we report the outcome of the cases in our institute of the fifty-year history.【Materials and Methods】We underwent 74 cadaveric renal transplantations and 152 living kidney transplantations. The mean age of recipients was 37±13 years, and the mean age of donor was 48±13 years. The cause of end-stage renal disease was chronic glomerulonephritis (n=174), the diabetic nephropathy (n=8), and other disease (n=44). The mean duration of dialysis prior to transplantation was 63 months.【Results】The follow-up period of the 226 patients was 9.3±8.9 years. We analyzed the cases of long-term allograft survival. 31 cases obtained graft survival period of more than 20 years (14%) and 5 cases (2.2%) obtained one of more than 30 years. The graft survival of cadaveric donor kidney transplantation at 5 years and 10 years was 65.4%, and 55.8%, and the graft survival of living donor kidney transplantation at 5 years and 10 years was 76.2%, and 70.1%. In the recognized loss of function of the 114 cases, cause of graft loss was chronic allograft dysfunction in 49 cases (42%), and the deaths in 41 cases (36%), and acute rejection in 19 patients (17%)【Conclusions】We summarized the 226 cases of kidney transplantation in Nagasaki University. Our clinical experience was considered to be history itself in Japan of kidney transplantation.