The Relationship between Parathyroid Hormone-intact Levels Before Renal Transplantation from Living Donors and Progression of Renal Damage in the Recipients

Abstract

【Introduction and aims】Chronic kidney disease-bone mineral disorders (CKD-MBD) is an important complication in CKD patients, and could affect long term prognosis of renal function after renal transplantation (TPL). We examined the influence of the factors associated with CKD-MBD on renal function before and 1-year after renal TPL.【Methods】We investigated 105 CKD patients who received renal TPL from living donors after 1995. The end point of this study was the 1.5-times increase of minimum serum creatinine (Cr) during the observational period after renal TPL, and examined the relation between CKD-MBD and renal function before and 1-year after renal TPL.【Results】During follow-up period, the 1.5-times increase in Cr occurred in 39 recipients (33.9%). It was associated with younger age, higher iPTH before TPL (p＝0.021) and lower hemoglobin 1-year after renal TPL (p＝0.003) compared with the recipients without the increase in Cr. The patients were separated into 2 groups with the median of iPTH before TPL (155 pg/mL), one group was the higher iPTH group；the other was the lower iPTH group. The Kaplan-Meier analysis showed the higher iPTH were significantly associated with the increase in Cr (p＝0.048).【Conclusions】The status of CKD-MBD before renal TPL might be associated with the progression of renal damage after renal TPL.