2016 Volume 4 Issue 2 Pages 221-226
【Objectives】Renal allografts from grandparents as well as parents are commonly used in pediatric living donor kidney transplantation (LKTx). The aim of this study was to investigate the impact of donor age on renal allograft function and histology.【Methods】We retrospectively analyzed clinical data of 63 recipients who were divided into three groups based on the donor age (30s, 40s, and over 50s). Outcome measures included eGFR after LKTx and ci/ct/ah scores determined by Banff classification in 0-hour and one-year protocol biopsy specimens.【Results】Maximum eGFR was lower and ci/ct/ah scores in 0-hour biopsy specimens were higher in the over 50s group than in the other groups. eGFR steadily decreased in all groups during one year of LKTx, lowest in the over 50s group. In one-year protocol biopsy, calcineurin inhibitor (CNI) toxicity was more frequently observed in the 40s and the over 50s groups than in the 30s group.【Conclusions】More careful management against CNI toxicity would be warranted in pediatric LKTx from donors aged over 50s.
