Abstract
Multicomponent crystals which contain API (active pharmaceutical ingredients) molecule are called as pharmaceutical cocrystals. Although there is currently some controversy regarding the classification and terminology for crystals consisting of more than one component, these systems are typically classified into salts, solvates (including hydrates) and cocrystals. Recently, the formation of cocrystal is attractive technique for improving the physicochemical properties of API. In this short review, screening and characterization of pharmaceutical cocrystals by using thermal analysis are introduced with advantages of cocrystallization in the development of solid dosage forms. In addition, preparing method of cocrystals for production scale by hotmelt extrusion technology is also described.
https://ror.org/05jk51a88 
