Abstract
Solid dispersion is recognized as promising formulation technology to improve solubility and bioavailability of poorly soluble compounds. However, its practical application for commercial products is still challenging because of its physical/chemical instability. It is very important to know why polymers in solid dispersions stabilize amorphous compounds for coping with challenges. Although stabilization mechamisms of polymer in solid dispersions have been reported, their details are still need to be investigated. In this review, the study results investigating the effets of polymers in solid dispersions agaist crystallization are introduced to establish theoretical rationale for selecting appropriate carriers of solid dispersions in formulation development of pharmaceutical products.
https://ror.org/01cjash87 
