1994 Volume 13 Issue 3-4 Pages 3-4_147-3-4_154
We collected histopathological findings in the eyes of the 259 cynomolgus monkeys used in the toxicity and pharmacological studies for developing new drugs during the past 13 years (April 1980-March 1993). The animals were aged 4 to 10 years. The eyes were removed just after euthanasia, fixed in 4% glutaraldehyde and post-fixed in 5% formalin. Routine paraffin sections were stained with H & E and examined by light microscopy.
Lesions were observed in the lens, ciliary body, and retina. The main findings were 1) inflammatory changes: mononuclear cell infiltration of the ciliary body in 16 animals (6.2%); 2) degenerative changes: cystoid degeneration of the peripheral retina in 9 animals (3.5%) and 3) congenital changes: retinal folds in 8 animals (3.1%). Other findings were conus of the optic nerve (0.8%) and cataract (0.4%). The conus was considered to be a congenital change and cataract to be a degenerative change with increasing age.
