Retinal prosthesis is a medical device designed to restore vision in patients who have lost sight due to photoreceptor degenerative disorders, such as retinitis pigmentosa, by electrically stimulating the remaining retinal neurons. Three major approaches—epiretinal, subretinal, and suprachoroidal implantation—have been developed, each with unique technical advantages and limitations. Clinical studies of devices such as the ARGUS II, Alpha IMS/AMS, PRIMA, and suprachoroidal-transretinal stimulation have demonstrated partial recovery of visual functions and modest improvements in daily activities. However, the level of vision achieved remains significantly below that of natural sight. This review summarizes recent advances in retinal prosthesis research, highlights clinical study outcomes, and discusses future prospects.
This paper discusses Electroretinogram (ERG) in cynomolgus monkeys used in non-clinical study. ERG involves stimulating the retina with light, and recording the resultant response as waveforms, thereby assessing retinal function. The retinal structure of cynomolgus monkeys closely resembles that of humans, making ERG data from cynomolgus monkeys highly contributory to the development of new pharmaceuticals and treatment methods. This article provides detailed descriptions of the measurement methods, waveform specifics, and responses based on the ISCEV standard, in addition to addressing important considerations during measurement. It is hoped that this paper will aid in advancing ERG research utilizing cynomolgus monkeys.
Veterinary ophthalmology has its roots in Europe, and early publications starting in the 1880s focused mainly on the horse eye. However, major political conflicts in this region of the world delayed further development in veterinary ophthalmology until well after World War II. In America, based on the success of the American Society of Veterinary Ophthalmology, and the growth and sophistication of private small animal practices in the 1950s, the American College of Veterinary Ophthalmologists (ACVO) was established in 1970. Final approval of the College by the American Veterinary Medical Association occurred in 1974. Similar veterinary ophthalmology specialization has occurred in the United Kingdom (certificate and diploma programs), Japan, France, Norway, Sweden, and other countries. The common market countries of Europe, and most recently, the Latin America countries have formed multiple country veterinary ophthalmology certification programs.
Practice of veterinary ophthalmology in the private sector has become both profitable and a stimulating professional career. Development of the specialty colleges, such as the American College of Veterinary Ophthalmologists in America, have been critical in the establishment of higher standards for the practice of veterinary ophthalmology, training of veterinary ophthalmologists, and the genesis and distribution of the majority of new information and scientific studies. Continued vitality of the ACVO-based academic programs depends on increasing the number of successful cooperative programs with the private specialty practices for clinical training of veterinary students and residents, and for clinical research. The future for veterinary ophthalmology is indeed bright!
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