Original Reports
Age-Related Spontaneous Ocular Lesions in Crj: CD (SD) IGS Rats
2001 Volume 20 Issue 1-2-3-4 Pages 21-25
Details
2001 Volume 20 Issue 1-2-3-4 Pages 21-25
The eyes were periodically examined on 150 male and 150 female Crj: CD (SD) IGS rats for up to 1 year with a slit lump and an indirect ophthalmoscope in order to survey age-related spontaneous ocular lesions. The pupil was dilated instillation of 0.5% tropicamide to facilitate the examination. Most of the ocular lesions observed in this study were of the type commonly seen in the Sprague-Dawley strain rat. The incidences of corneal opacity and lenticular opacity were generally increased with increasing age. Anterior subcapsular lenticular opacity found in Crj: CD (SD) IGS rats was a new spontaneous ocular lesion which has not been reported in Japan.
