2004 Volume 23 Issue 1-2 Pages 1-2_19-1-2_21
We examined the acute inflammatory response of five the Japanese White rabbits following paracentesis by investigating the breakdown of the blood-aqueous barrier (BAB). Nitrite, prostaglandin E2, and protein accumulations in the aqueous humor were measured after paracentesis. Thirty minutes after collecting the rabbit's primary aqueous humor, the secondary aqueous humor was collected. Nitrite, prostaglandin E2, and protein concentrations in the secondary aqueous humor had significantly increased compared with those of the primary aqueous humor; the average concentrations in the former being 6.55 ± 1.05 μmol/l, 274.42 ± 10.37 pg/ml, and 22.70 ± 5.70 mg/ml, respectively, while those in the latter were 4.11 ± 0.54 μmol/l, 3.34 ± 0.11 pg/ml and 3.69 ± 0.20 mg/ml, respectively. These findings indicated the possibility that the change of NO in the aqueous humor following paracentesis plays an important role in the breakdown of BAB in connection with prostaglandin E2 and protein.
