1984 Volume 3 Pages 13-16
Apparently healthy 523 colony-born cynomolgus monkeys (Macaca fascicularis) aged from 0 day to 19 years were examined for the findings of the ocular fundus by using ophthalmoscope. One drop of the mixed solution of 0.5% tropicamide and 0.5% phenylephrine hydrochloride was instilled into each eye of the animal. Then, those monkeys were anesthetized with ketamin-HCl at the dose level of 10mg/Kg B.W.. Either with or without pre-injection of fluorescein in, photographs were taken with Kowa RC-II ophthalmoscope-camera by using daylight typed color film. The flash intensity for taking regular photographs was set at 50W-2 and fluorescein angiographs were set at 100W of the transformer's position.
Following findings were obtained in each age class. Retinal color was salmon pink with 0 to 3-day-old neonates, salmon pink and blue to green with 3-week to 4-week-old animals, blue to green with 6-week to 1 year old macaques, and brown with 7-year-old monkeys. As regards optic disc, 0- to 3-week-old animals were observed to be light orange in color, and the infants aged more than 4-week showed orange color. Retinal arteries and veins were lightly reddish in the color with every age class. Macular color was salmon pink in 0-day-old cases, slightly dark in 3-day-old neonates and very dark after 3-week of age. Little retinal reflex was noted in 0 and 1-week-old animals. The reflex was observable in 2-week-old animals without fail, attaining the strongest intensity in 1-year-old monkeys and gradually decreasing its intensity in 3- to 19-year-old animals. Central pit's reflex was detectable after 6-month of age. Retinal hemorrhages were recorded about 70% neonates born in natural condition. It was noted that retinal hemorrhages disappeared at 3-day to 2-week of age. Persistent hyaloid artery was observed in all newborn monkeys. It was noted that persistent hyaloid artery was faded out at 3 to 6-week of age.
