2019 Volume 52 Issue 2 Pages 101-108
We investigated the influence of exercise intensity during hemodialysis on the removal of small, medium, and large solute molecules. Out of 285 hemodialysis patients who were enrolled in our hospital, 17 were eligible for the study. Each patient completed two trial arms (the routine hemodialysis arm and the exercise during hemodialysis arm) in a randomized order. Dialysate and blood samples were collected at hourly intervals on the first hemodialysis day of the week and used to measure potassium (K), phosphate (P), blood urea nitrogen (BUN), β2-microglobulin (β2MG), α1-microglobulin (α1MG), and albumin (Alb) levels. A cardiopulmonary exercise test was used to obtain anaerobic threshold (AT) measurements for each subject. The patients were classified into two groups, the below AT group, whose exercise intensity was below the AT, and the AT group, whose exercise intensity was at or above the AT level. In comparison with routine hemodialysis, the amounts of K, P, and BUN removed increased during exercise in the below AT group, while the amounts of P and BUN removed decreased after exercise in the AT group (p<0.05). The amount of α1MG removed increased in both exercise intensity groups (p<0.01), while those of β2MG and Alb remained unchanged throughout the study period. These findings suggest that low-intensity exercise during hemodialysis might enhance K, P, BUN, and α1MG removal during hemodialysis without causing Alb loss.
