Abstract
There are not infrequent increase in blood pressure during hemodialysis, particularly at the time of termination of the dialysis and residual blood return. In an attempt to evaluate rapid antihypertensive action of Nifedipine, changes in blood pressure of nine patients with acute and chronic renal failure undertaking hemodialysis were studied. In addition, hemodynamic parameters were obtained by means of Swan-Ganz thermodilution catheter inserted through the right femoral vein.
As a result, antihypertensive effect was taking place within 15 minutes following oral administration of the drug and mean blood pressure (MAP) and total systemic peripheral resistance (TSPR) were decreased significantly, whereas cardiac index (CI) and heart rate (HR) revealed slight and statistically insignificant increase. Changes in diastolic pressure of pulmonary artery (PAd) and mean right atrial pressure (RA), which were closely related to preload on the heart, were not significant. However, the antihypertensive effect was apparently enhanced in the state of reduced preload.
In conclusion, it may be considered that oral administration of Nifedipine is effective for the purpose of rapid reduction of blood pressure on the hypertensive crisis during or after the hemodialysis.
