Abstract
This paper discusses the solute removal dynamics in CAPD. Newly defined characterization parameters, namely, time-averaged clearance CL and concentration (CS) in stable periods, are introduced into the comparison of removal dynamics in several hemopurification modalities. These parameters are calculated from the solute concentration and the conventional clearance by compartment model.
As a result, only in CAPD the calculated values of (CS) for low molecular metabolites are higher than clinically obtained values. The solute generation rate (G) of these substances in six CAPD patients decreased by 20-30% of the value obtained when the patients were treated with HD.
The molecular weight (MW) -CL profile in CAPD is similar to that in HF, but the MW-CS profile in CAPD is similar to that in HDF because of the reduced G in low molecular metabolites.
