Journal of Japanese Society for Dialysis Therapy
Online ISSN : 1884-6203
Print ISSN : 0288-7045
ISSN-L : 0288-7045
Cell growth inhibition factor from plastics
Tomokazu SegawaAkira MatsukawaKazuko SataHajime Inamoto
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1983 Volume 16 Issue 5 Pages 325-330

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Abstract
In order to determine the toxicity of plastics in madical use, the effect of their extracts on cells were examind.
The addition of water and saline extracts to cell cultures had no effect on the growth of L-929 cells. However, the growth was inhibited by adding ethanol and serum extracts of ethylene-vinylacetate copolymer, non-plasticized and plasticized polyvinyl chloride to the culture. The degree of inhibition depended on the dose of the extracts. Morphological changes in the cells were also observed when these extracts were added to the culture.
Water and saline have been principally used as the eluants of plastics for safety evaluation. The results indicate the necessity of safety evaluation using fat-soluble extracts as well, in regard to medical devices which must contact the blood.
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© The Japanese Society for Dialysis Therapy
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