Gabexate mesilate (GM) 透析におけるGMおよびその代謝物の動態 (第2報) GM反復回路内持続注入後のGMおよびその代謝物の体内動態

石黒 源之; 安江 隆夫; 渡辺 佐知郎; 澤田 重樹; 遠渡 豊寛; 古田 昭春; 沢田 正文; 石堂 雅恒; 仲宇佐 雅子; 宮本 茂敏

doi:10.4009/jsdt1985.21.47

Study on the pharmacokinetics of gabexate mesilate (GM) and its metabolites during hemodialysis (the second report)

Motoyuki Ishiguro, Takao Yasue, Sachiro Watanabe, Shigeki Sawada, Toyohiro Endo, Akiharu Furuta, Masafumi Sawada, Masatsune Ishido, Masako Nakausa, Shigetoshi Miyamoto

Author information

Keywords: hemodialysis, GM (gabexate mesilate), GCA (guanidinocaproic acid), EPHB (ethyl-p-hydroxybenzoate), PHB (p-hydroxybenzoic acid)

JOURNAL FREE ACCESS

1988 Volume 21 Issue 1 Pages 47-54

DOI https://doi.org/10.4009/jsdt1985.21.47

Details

Abstract

The pharmacokinetics of gabexate methylate (GM) (five consecutive administrations) during hemodialysis were studied by measuring the plasma levels of its metabolites (GCA, EPHB, PHB, and glucuronide conjugate of EPHB and PHB). Plasma levels of GM metabolites did not change after the third GM hemodialysis. They decreased after GM had been replaced by heparin, and GM metabolites were no longer detected in plasma after one month.

Corresponding author

Register with J-STAGE for free!