Blood purification system for the chronic hepatic failure using urethanesheet embedded with powdered charcoal (UPC, BESPORETM)

Abstract

A blood purification system has been developed for use in an artificial liver support system using urthane-sheet embedded with powdered charcoal (UPC, BESPORETM) prepared mainly for the purpose of effectively adsorbing protein-bound and middle-molecular substances. This system consists of UPC-plasmaperfusion followed by supplementary therapy with plasmaexchange for the purpose of performing both removal and supplementary therapy at the same time. This liver support was performed in and the remaining two cases of chronic hepatic failures (Primary and secondary biliary cirrhosis) for 6 months (21 times) and 3 months (15 times), respectively, reculfing in prolonged life. The amounts of bililubin and bile acids removed by UPC-plasmaperfusion was 40%.