Abstract
To clarify the causes of gastric mucosal lesions in patients with chronic renal failure, the incidence and location of mucosal lesions in the stomach were investigated endoscopically in patients on maintenance hemodialysis treatment (HD patients; n=137). Serum HCO3- concentration (n=66), gastric mucosal blood flow (GMBF; n=46) and the presence of Campylobacter pylori (n=23), which has been claimed to be related to certain gastric lesions, were also investigated. Erosive gastritis, gastric ulcer and acute gastritis were the main source of the lesions in the HD patients and were mainly localized in the gastric antrum. Acute gastritis lesions were also found in the gastric body (66.7%), except the antrum. Serum HCO3- and GMBF in the upper body greater curvature of HD patients were lower than in healthy controls, while the rate of detection of Campylobacter pylori was 43.5%, with no significant differences.
As a result, it has been suggested that deficiency of such gastric protective factors such as mucosal HCO3- secretion and GMBF may contribute to the occurrence of gastric lesions in chronic renal failure.
