Pharmacokinetics of nafamstat mesilate (FUT) in patients undergoing hemodialysis

Abstract

The influence of renal failure and hemodialysis on the anticoagulant effects of FUT was studied in 8 patients under going hemodialysis (HD group) and 5 healthy volunteers (Nr group). To determine FUT kinetics, serum concentration (by HPLC) and celite activated clotting time (ACT) were examined after 0.3mg/kg FUT administration. FUT showed very rapid and short action as an anticoagulant agent, with an effective serum level over 1, 580ng/ml.
FUT kinetics of the HD and Nr groups, respectively, were as follows: volume of distribution (Vd) 0.08±0.07/0.36±0.23l/kg; total body clearance (CL) 0.02±0.01/0.07±0.04ml/min/kg; elimination half lives (t1/2) 1.04±0.60/1.73±1.49min; elimination rate constant (Kel) 0.83±0.36/0.64±0.40min^-1. The HD group showed smaller CL and Vd (probably from A-V fistule), but shorter t1/2 and higher Kel than the Nr group.
These results suggest that there were no clinical differences in FUT kinetics between the HD and Nr groups.