Abstract
Short-time dialysis (3hrs) was evaluated with respect to various clinical factors.
Using a high performance membrane (HPM), under the conditions of blood flow (QB)=314ml/min and dialysate flow=500ml/min, 1) KT/V, TACBUN, PCR were 1.35±0.17, 46.6±7.1mg/dl, 1.20±0.18g/kg/day, respectively. The average reduction in β2 microglobulin was 42.6±6.3mg/dl. 2) Cardiac functions examined by the Swan-Ganz catheter method showed that an increase in QB did not affect MBP, HR, CI, CVP, PCWP or PA. 3) The endotoxin concentration of the dialysate was 2.7pg/ml. 4) No difference was found in clinical data (CTR, blood pressure and blood test parameters) between conventional HD and short-time HD. 5) Shortening of the HD time seemed to be beneficial to the patient's quality of life.
We conclude that shortening of the HD time does not influence the adequacy of HD, if HPM and high QB are properly chosen. We also suggest that an increase in QB has no substantial effect on cardiac functions.
