Abstract
We report a case of prednisolone-responsive cisplatin-induced acute renal failure.
A 64-year-old man who suffered from advanced gastric cancer, received continuous hyperthermic peritoneal perfusion (CHPP) of cisplatin (300mg) at the time of total gastrectomy. Normal renal function deteriorated acutely following the operation. Five days after the operation, he became anuric and the serum levels of BUN and creatinine rose to 70mg/dl and 9mg/dl, respectively. He therefore underwent hemodialysis. Two weeks after the initiation of hemodialysis, diuresis occurred, but serum creatinine levels did not improve. Renal biopsy was performed at 74 days after the operation, when creatinine was 10mg/dl and it disclosed almost normal glomeruli and marked cellular infiltration of the interstitium, especially in the region of the corticomedullary junction. Therapy with prednisolone resulted in a fall in the serum creatinine level, which decreased from 10mg/dl to 5mg/dl. Our case suggests the effectiveness of prednisolone therapy for cisplatin-induced acute renal failure.
