Abstract
We report 2 cases suffering from paroxysmal nocturnal hemoglobinuria (PNH) with acute renal failure (ARF) who completely recovered from ARF with the aid of hemodialysis (HD).
Case 1 was diagnosed as PNH in 1986, then took prednisolone (PSL) and was in good general condition. In 1992, she suddenly developed AFR after a hemolysis attack. She was given haptoglobin, washed RBC, and 60mg of PSL p. o., and HD was performed 8 times to treat ARF. Case 2 was diagnosed as PNH in 1974, and then treated with washed RBC infusion, fluoxymesterone, and PSL. In 1991, he suffered from ARF just after a hemolysis attack, but recovered from ARF after 12 HD sessions. Renal biopsy was performed in the latter case. The histopathological findings of the specimen included almost normal glomeruli, remarkable iron deposition in renal tubular epithelial cells, and the degeneration of the renal tubules.
