Abstract
We measured plasma concentrations of pyridinoline (Pyr) and deoxypyridinoline (Dpyr), markers of bone resorption, by high-performance liquid chromatography in 34 patients on maintenance hemodialysis. As controls, 13 adults with normal renal function were employed. Pyr was undetectable in 7 of the controls (the detection limit of both Pyr and Dpyr: 3pmol/ml). The highest Pyr value in the controls was 7pmol/ml. Dpyr was undetectable in all controls. In all hemodialytic patients, both Pyr and Dpyr values were several to tens times higher than those in controls. There was a very close correlation between Pyr and Dpyr (r=0.955, p<0.001) in the hemodialytic patients. When comparing the mean values of Pyr or Dpyr, by dividing the hemodialytic patients into two groups according to the C-PTH value of each patient with a cut-off value of 2.5, 5.0 or 10.0ng/ml, there were statistically significant differences between each group on certain occasions. Both Pyr and Dpyr showed close correlations with PTHs (C- and M-), osteocalcin and tartrate resistant acid phosphatase (p<0.001), known renal osteodystrophy markers. Neither Pyr nor Dpyr correlated with the duration of hemodialysis. These results indicate plasma Pyr and Dpyr are useful parameters of renal osteodystrophy.
