Abstract
β2-Microglobulin (β2M) isolated from the amyloid tissue of patients with dialysis-related amyloidosis (DRA) has been reported to be modified by advanced glycation end products (AGE) via the Maillard reaction. We produced anti-AGE monoclonal antibody and used it to immunohistochemically localize AGE in amyloid tissue obtained during surgical operations on patients with carpal tunnel syndrome (CTS). AGE was found to be localized in β2M-positive amyloid tissues. AGE was also detected in infiltrating cells surrounding the amyloid tissue. In conclusion, β2M-positive amyloid tissue was immunohistochemically demonstrated to be modified by AGE.