Report of a case of a hemodialysis patient with Laurence-Moon-Bardet-Biedl syndrome complicated by gastric cancer

Abstract

A 39-year-old man with Laurence-Moon-Bardet-Biedl syndrome (LMBB syndrome) was admitted because of severe anemia in spite of frequent blood transfusions. He had an 18-year history of NIDDM. Hemodialysis had been instituted one year before hospitalization because his renal function had grown worse. Gastroenoscopic examination performed after admission revealed advanced gastric cancer (Borrmann type III). The patient died of gastric cancer complicated by carcinomatous peritonitis, obstructive jaundice and DIC syndrome.
Renal involvement has recently been reported in LMBB syndrome. Although the patient had a long history of NIDDM, autopsy data showed histopathological changes which included the mesangial proliferation and interstitial fibrosis previously described in LMBB syndrome, but no typical changes of diabetic nephropathy.
We concluded that renal involvement in LMBB syndrome may have caused the deterioration of this patient's renal function.