Abstract
The authors derived a novel simple peritoneal transport equation for small solutes based on the most rigorous Pyle-Popovich's model. Computational curve-fittings were calculated for data generated by the Pyle-Popovich's model using three simple kinetic equations, i.e., Henerso's (no convection), Babb-Garred's (convection from blood to dialysate only), and new model that includes more precise effects of convection, to determine which of these three models returned most accurate MTAC (overall Mass Transfer-Area Coefficient) value. The mathematical forms of these three equations are remarkably similar, although the basic concept or assumptions for derivation are totally different. Slight discrepancies were found between these three models when 4 hr-concentration data were used. Considerable errors, however, appeared with the former two models for data obtained in the case of “UF failure” or “Excess UF”, especially when shorter time (less than 2 hrs) for data collection was used. Even, under such circumstances, the new simple model calculated accurate MTAC values with small error rate (±5.0%). Since analyzing patients' peritoneal function is becoming more important these days, the new kinetic model that requires only PET (peritoneal equilibrium test) data may be a useful tool for calculating MTAC values.
