Abstract
The present study used antimicrobial consumption surveillance to assess the resistance rate transition of Pseudomonas aeruginosa in facilities cooperating in infection prevention medical fees using the antimicrobial use density (AUD) and days of therapy (DOT) as parameters, and compared the surveillance results in 2014 to 2012. In our hospital, the change in DOT of first-generation cephalosporins, third-generation cephalosporins, fourth-generation cephalosporins, carbapenems, aminoglycosides, glycopeptides was greater than that of AUD. In stroke center, the change in DOT of penicillins, antipseudomonal penicillins, carbapenems was greater than that of AUD. The surveillance comparing the AUD transition with DOT transition revealed the influence of antimicrobial dose and duration on the change of AUD was more accurately evaluated by surveillance using the AUD transition with DOT transition. In both facilities, the antimicrobial dose and duration were not associated with change in the resistance rate of P. aeruginosa. The present results suggest that the effects of change in antimicrobial dose and duration transition on the change in resistance rate of P. aeruginosa are limited.
