内耳内・外リンパ液の循環代謝動態

第3編レーザードップラー法での測定-浸透圧利尿剤の影響-

抄録

Cochlear blood flow was measured with a Laser Doppler flowmeter. The methods and the dose infused were as described in Chapter 2. Recordings from the basal turn of 6 guinea pigs in each group were examined in a study of the effects of hyperosmolar solutions of glycerol, mannitol, and urea. Recordings were made for 10 minutes beforre infusion and for 10 minutes after glycerol, mannitol, or urea infusion. Cochlear blood flow increased significantly after the infusion of glycerol. In contrast, in 6 guinea pigs there was no significant increase of cochlear blood flow after infusion of the same volume of physiological saline. Cochlear blood flow increased significantly after the infusion of mannitol, but not after the infusion of urea. A personal computer (NEC PC-9801) and soft ware made by ourselves were used to analyze these data. These results do not agree with those obtained by the H₂ clearance method.