実験的内リンパ水腫モルモットの蝸牛血流と血圧
1991 年 50 巻 Suppl-7 号 p. 144-146
詳細
1991 年 50 巻 Suppl-7 号 p. 144-146
The effect of blood pressure (BP) changes on cochlear blood flow (CoBF) was investigated in anesthetized ginea pigs. CoBF was measured by the laser Doppler (LD) technique while systemic BP was modulated by intravenous infusions of norepinephrine or by the removal of whole blood. CoBF changed passively in the mean BP range of 40 to 90 mmHg, however, it showed effective autoregulatory function when BP decreased below 40 mmHg. In the guinea pigs with unilaterally obliterated endo-lymphatic sac and duct, the decrease in CoBF 3 to 7 months after surgery was larger on the operated side than on the intact side. This suggests that autoregulatory function for CoBF is impaired in the hydropic ear.
