In the past years significant advances have been made in our understanding of the functional significance of free radicals in the inner ear. This localization of free radical production sites has now been established by immunohistochemistry and the fluorescent indicator of NO and ROS. Increasing evidence suggests that excessive free radical production may play an essential role in vestibular disorders. Based on the mechanisms of inner ear disorders, new pharmacological strategies for preventing and/or treating vestibular disorders have been also suggested.