Abstract
Generally, it is known that ultrasound application (UA) induces fat mobilization through increasing in norepinephrine secretion from sympathetic nerves in the white adipose tissue. On the other hand, Kurosu, a vinegar made from sweet potatos, has been reported to improve lipid metabolism. In this study, we have examined the effect of combined treatment with UA plus Kurosu administration on fat mobilization, and analysed the changes of serum Triglyceride (TG) and Free Fatty Acids (FFA) . The rats were administered 5 times/week with 4 mg/kg or 400 mg/kg of Kurosu by gastric intubation for a month. At the same time, the rats were subjected to the application of 715kHz ultrasound for 30 min at twice/week. After 14 times and 24 times of Kurosu administration (6 and 10 times of UA, respectively), significant decrease in the non-fasting serum FFA was observed in Kurosu and UA combined treated rats compared with control rats administered distilled water. Moreover, the rates of increase in serum TG and FFA before and 1 hr after the UA were correlated with the dose of Kurosu, and were higher than that of control group. These findings suggest that the lipolytic effect of Kurosu was further promoted by UA.
