Fish Pathology
Online ISSN : 1881-7335
Print ISSN : 0388-788X
ISSN-L : 0388-788X
Short Communications
Upper Temperature Limits for the Multiplication of Betanodaviruses
Naomi HataYasushi OkinakaTakahiro SakamotoTokinori IwamotoToshihiro Nakai
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2007 Volume 42 Issue 4 Pages 225-228

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Abstract

Among the four types of betanodaviruses, redspotted grouper nervous necrosis virus (RGNNV) has the highest optimum temperature (25-30°C) for its multiplication. We tested 16 RGNNV isolates for their temperature sensitivity in cultured cells and demonstrated that their upper temperature limits ranged from less than 30°C to 35°C. At the temperatures over the upper limits, viral RNA replication was inhibited similarly. These results indicate that temperatures mainly affect RNA replication or earlier virus multiplication processes. The incompetence of betanodaviruses at 37°C suggests their avirulence in human.

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© 2007 The Japanese Society of Fish Pathology
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