Fish Pathology
Online ISSN : 1881-7335
Print ISSN : 0388-788X
ISSN-L : 0388-788X
Short Communications
The Expression Analysis of Innate Immune-related Genes in Kuruma Shrimp Penaeus japonicus after DNA Vaccination against Penaeid Rod-shaped DNA Virus
Tomoya KonoKohei SonodaYoichi KitaoTohru MekataToshiaki ItamiMasahiro Sakai
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2009 Volume 44 Issue 2 Pages 94-97

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Abstract

In this study, we have developed a DNA vaccine encoding viral envelope protein VP28 of penaeid rod-shaped DNA virus (PRDV, = WSSV). Protective efficacy of the DNA vaccine against PRDV was confirmed at 7 days post vaccination in kuruma shrimp Penaeus japonicus. The VP28 transcript derived from the vaccine was detected in various tissues at 1, 3 and 7 days post vaccination. Moreover, notable up-regulated expression of Rab7, penaeidin, lysozyme and crustin genes was observed upon DNA vaccination. These results suggest that the DNA vaccine significantly increased the protection and innate immune responses in kuruma shrimp against PRDV.

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© 2009 The Japanese Society of Fish Pathology
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