1979 Volume 14 Issue 2 Pages 93-101
The efficacy of piromidic acid (PA) against various bacterial diseases in cultured fish was evaluated clinically. PA was used for the treatment of furunculosis in Amago (Oncorhynchus rhodurus), Yamane (O. masou) and brook trout (Salvelinus fontinalis), vibriosis in rainbow trout (Salmo gairdneri), êdwardsiellosis and red disease in eels (Anguilla japonica).
PA was mixed in feed and consecutively administered for 5-11 days at the rate of 10, 20 and 40 mg/kg. The fish in every disease responded to PA with reduction in mortality and were found to be cured of the disease during medication or within a few days post dosing. The efficacy of PA against furunculosis was more remarkable than those of sulfisozole and sulfamonomethoxine (100-200 mg/kg/day). When PA was administered to Amago with furunculosis at 10 mg/kg for 5 days, mean blood levels in diseased fish were found to be 0.81, 1.50 and 1.39μg/ml 3 hours post dosing on 1st, 3rd and 5th day of the medication, respectively. It was revealed that PA was well absorbed in the diseased fish without a marked difference in its absorption among them.
The administration of PA caused no abnormality in 120, 000 fish of salmonids and 320, 000 fish of eels including elvers. The results obtained from this study suggest that PA can be used for the control of bacterial diseases in salmonids and eels.
