Abstract
In vitro antimicrobial activity of bicozamycin (BCM), a cell wall synthesis inhibitor, was investigated against Pasteurella piscicida. Minimum inhibitory concentrations (MIC) of BCM against 263 clinical isolates of P. piscicida ranged from 1.56 to 6.25μg/ml. High incidence of drug-resistant strains agains other drugs such as β-lactamam antibiotics and pyridonecarboxylic acids were recognized. No cross resistance between BCM and other antibacterial agents were observed. BCM displayed bactericidal activity at its MIC level.
P.piscicida strains showed a slowly increasing and stepwise pattern of artificial developmen of resistance against BCM.
From the results obtained, it may be suggested that BCM would be applied as a new type of therapeutic agent among the cell wall synthesis inhibitors for the treatment of pseudotuberculosis.
