Abstract
The objectives of this study was to evaluate the clinical characteristics of BRCA mutation carriers with carcinoma of the ovary / fallopian tube. Median age at genetic diagnosis was 52y.o. Dignosis of BRCA mutation was made before ovarian cancer surgery in two patients, including one patient who presented with stage Ⅲc ovarian cancer in periodic screening. In other eight patients, genetic test was performed after the ovarian cancer surgery, including four patients with family histories suggestive of hereditary breast and ovarian cancer. The most common histologic type was serous adenocarcinoma of the ovary / fallopian tube, although in this series two relatively rare cases with mucinous borderline tumor of the ovary with BRCA2 mutations was reported. Primary debulking surgery was performed in nine patietns and optimal resection was achieved in seven patients. Five patients recurred, and were given salvage surgery and / or chemotherapy and at present all the patients survived, suggesting a relatively good prognosis in BRCA mutation carriers with carcinoma of the ovarian / fallopian tube.
