Abstract
Five to ten percent of all breast cancer cases are thought to be hereditary, and the BRCA1/2 gene mutation is known to be involved. Individuals with the BRCA1/2 gene mutation have a higher risk of developing hereditary breast and ovarian cancer （ HBOC） . Patients and family members with family histories of cancer in Europe and America receive genetic counseling and genetic testing for treatment, diagnosis, and the prevention of symptoms. It is difficult that genetic screening may be performed, and these cope all only in heredity specialty outpatient department, and it is expected that even a breast specialty clinic copes, and testing is not performed in all cases. In total 303 individuals who visited our outpatient clinic were diagnosed with or treated for breast cancer between January 2010 and January 2014. We interviewed these patients about their family histories, identified high-risk HBOC individuals, and gave genetic counseling to 114 individuals. In total 711 individuals who treated with breast-conserving surgery our patient clinic were diagnosed with or treated for breast cancer between April 1988 and April 2014. We diagnosed of 40 ipsilateral breast cancers. We diagnosed of 39 contralateral breast cancers between April 1988 and April 2014. A tissue diagnosis was provided before surgery for 298 breast cancer, and unilateral mastectomy was chosen for 23 HER2-positive breast cancer of Intrinsic subtype by 56.5% between January, 2010 and April, 2014. We are unable to readily determine why so many individuals are reluctant to visit our breast special clinic. We examine BRCA1/2 mutation in the gene and want to determine treatment in future. Ongoing genetic counseling is recommended.
