子宮魚鱗癬を伴った子宮体部類内膜癌の１例

抄録

　Ichthyosis uteri is a rare condition where an extensive portion of the surface endometrium is replaced by stratified squamous epithelium. Although ichthyosis uteri is considered a benign disease, it has recently been associated with malignant tumors. Here we report a case of ichthyosis uteri complicated by endometrioid carcinoma.

　A 58 years old female patient visited her previous physician with a chief complaint of irregular bleeding. Endometrial cytology revealed atypical cells derived from squamous metaplasia. The patient was referred to our hospital for a detailed examination. The results of the endometrial histological examination revealed a squamous cell component. A similar result was obtained upon examining the endometrial scraping samples. Based on these findings, the patient was diagnosed with ichthyosis uteri.

　It is reported that ichthyosis uteri is often associated with malignancy; therefore, a contrast-enhanced magnetic resonance imaging was performed. A 3 cm large mass protruding from the posterior wall of the uterus was observed with high signal on diffusion-weighted images. A preoperative diagnosis of stage IA uterine cancer was suspected. An extended total laparoscopic hysterectomy and bilateral adnexectomy were performed.

　Histopathological examination revealed ichthyosis uteri with extensive superficial coverage of the squamous epithelium and a deep internal endometrioid carcinoma. The carcinoma was diagnosed with stage IA uterine cancer and G1 endometrioid carcinoma with vascular invasion.

　Squamous cell and verrucous carcinomas have frequently been reported as uterine carcinomas arising in the setting of ichthyosis uteri. Here we report a rare case of endometrioid carcinoma associated with ichthyosis uteri and perform a literature review.