Association of blood pressure and body mass index with intraocular pressure in middle-aged and older Japanese residents

抄録

Purpose : To determine whether systolic blood pressure (SBP), diastolic blood pressure (DBP), and body mass index (BMI) are associated with elevated intraocular pressure (IOP).
Methods : This cross-sectional study analyzed health examination data obtained between 2001 and 2004 from 1,113 Japanese individuals (age range, 28-79 years) who had not undergone any ocular surgery or medical treatment for hypertension, ocular hypertension, and glaucoma. The association of SBP, DBP, and BMI with IOP were evaluated by multiple regression analyses and analyses of covariance.
Results : Multiple-regression analysis showed that SBP, DBP, and BMI had a significantly positive association with IOP in both sexes (P<0.05 with the exception of BMI in model 2 for women where P=0.06). Analysis of covariance found that the adjusted mean IOP increased with increasing SBP, DBP, and BMI in both sexes (P for trend<0.05).
Conclusions : SBP, DBP, and BMI were positively associated with IOP in middle-aged and older Japanese men and women. Therefore, management of blood pressure and improvement of obesity might be especially important to Japanese patients with open-angle glaucoma or ocular hypertension, as they have a higher incidence of normal tension glaucoma than Western populations.
Key words : intraocular pressure, blood pressure, body mass index, epidemiology, glaucoma