Association between change in fatty acid binding 4 concentration and cardiovascular diseases risk factors after weight loss in adults

Abstract

BACKGROUND：Fatty acid binding protein 4（FABP4）is one of adipokines. Blood FABP4 concentration is associated with cardiovascular diseases risk factors. OBJECTIVE：The purpose of this study was to investigate the association between change in fatty acid binding 4 concentration and cardiovascular diseases risk factors after weight loss by combined dietary restriction and exercise in adults. METHODS：Thirty-two men and women participated in 3-months or 6-months weight loss program. The program consisted of dietary restriction and exercise. Body composition（body weight and fat mass）, cardiovascular diseases risk factors（blood pressure, high-density lipoprotein cholesterol［HDLC］, low-density lipoprotein cholesterol, triglycerides［TG］and fasting plasma glucose［FPG］）, adipokines（FABP4, adiponectin［ADPN］, leptin［LP］, and interleukin-6［IL-6］） were measured before and after the program. RESULTS：Body weight and fat mass signifi cantly decreased by 3.6 kg and 2.7 kg, respectively after the program. HDLC and TG concentration also signifi cantly improved after the program. Signifi cant improvements in ADPN, LP, and FABP4 concentration were observed. Changes in FABP4 concentration was positively correlated with change in FPG （r =0.632，q =0.066）. Moreover, change in ADPN were signifi cantly positively correlated with change in HDL concentration （r =0.758, q =0.015）. CONCLUSION：These fi ndings suggest that weight loss-induced change in FABP4 concentration plays an important factor to improve cardiovascular diseases risk factors.