特集：「圧力に対する生体応答機構の理解に向けて」
小胞体局在タンパク質Ehg1とEhg2を利用した出芽酵母の高水圧環境生存戦略
2026 年 36 巻 1 号 p. 4-11
詳細
2026 年 36 巻 1 号 p. 4-11
High-pressure environments exert significant impact on cellular survival. In Saccharomyces cerevisiae, two endoplasmic reticulum (ER)-localized proteins, Ehg1 and Ehg2, are essential for growth under 25 MPa hydrostatic pressure. Ehg1 is a cytoplasmic peripheral membrane protein containing a critical PXFP motif for its function. Ehg2 is a two-pass transmembrane protein characterized by conserved luminal domains, essential N-glycosylation sites, and a vital cytoplasmic GVPS motif. Both proteins stabilize nutrient permeases by preventing their degradation under high-pressure conditions, thereby maintaining nutrient uptake. These findings reveal a unique adaptive strategy in which ER-localized proteins preserve membrane protein integrity during mechanical stress.
