Abstract
Objectives: The purpose of the study was to investigate the clinical and prognostic effects of recombinant thrombomodulin (rTM) for sepsis-induced disseminated intravascular coagulation (DIC), compared with danaparoid sodium (DS). Methods: A single center retrospective observational study of 73 patients with sepsis-induced DIC was performed from January 2006 to December 2010. Results: The patients were classified into rTM (n = 33), and DS (n = 40) groups. Patients in the rTM group had a DIC score ≥5 or a DIC score of 4 and a platelet score of 3, and were treated with rTM. Those in the DS group met the same criteria and were treated with DS. In the rTM group, platelet count showed a significant increase after Day 4. The antithrombin (AT) values significantly increased in the rTM and DS groups in Day 4 compared with Day 1. The D-dimer values did not change significantly in any of the groups. The rTM group had significantly better long-term outcome than the DS group. However, after adjusting for Sequential Organ Failure Assessment score without Glasgow coma scale(SOFA–CNS), intra abdominal sites, pneumonia, rTM did not significantly affect the 28-day mortality. Conclusions: These results show that rTM is effective for treatment of septic DIC, with good recovery of the platelet count and good long-term prognosis (P < 0.01). However, rTM did not significantly affect the 28-day mortality.
