Abstract
Background: The aim of this study was to evaluate the impact of cardio-renal syndrome type 1 (CRS-1) on hospitalacquired disability (HAD) in patients with acute decompensated heart failure (ADHF). Methods: A total of 958 adult ADHF patients (female 45%, age 77±13 years) who underwent acute-phase cardiac rehabilitation between 2013 and 2018 were enrolled in this study. Patients were assigned to HAD group with defined as a decrease in Barthel index (BI) of at least 5 points at discharge compared with pre-admission BI. CRS-1 was defined as a creatinine criteria of The Kidney Disease: Improving Global Outcomes (KDIGO) Guideline for acute kidney injury. Multivariate logistic regression analysis was used to identify the predictors of HAD in patients with ADHF. Results: The prevalence of CRS-1 was significantly higher in patients with HAD than in those without HAD (21.2 vs. 11.6%, P = 0.002). In multivariate logistic analysis, CRS-1 was associated with HAD independent of age, albumin, and completion of early mobilization (OR : 2.064, 95% CI : 1.160 - 3.675, P = 0.014) . Conclusion: CRS-1 is independently associated with HAD in patients with ADHF.
