Abstract
We compared effect of CPD (citrate, phosphate, dextrose) and MAP (mannitol, adenine, phosphate), a new preservation solution for the concentrated red cells, on the time course changes in neutrophil elastase·α1-antitrypsin complex (EAC) and white blood cell counts in the concentrated red cells (CRC). All samples, MAP-CRC or CPD-CRC, were made from bloods withdrawn from 7 volunteers and they were stored in a refrigerator with its temperature kept at 4°C during the study. EAC level in the CPD-CRC sharply increased from 7 to 42 days after withdrawal. However, EAC level in the MAP-CRC started to increase from 14 days after sampling and this increase in EAC was statistically lower than that in CPD-CRC at each preservation date. White blood cells in MAP-CRC decreased more slowly than those in CPD-CRC. These results indicate that MAP delayed the rate of an increase of EAC in stored blood. These differences of EAC level between MAP-CRC and CPD-CRC may depend on the removal rate of white blood cells from the blood as well as the decay of white blood cells for the preservation day.
