Abstract
Nitric oxide (NO) synthesized from an amino acid L-arginine has become one of the most notable substance in the central nervous system in the present decade. NO is supposed to mediate the long-term depression in the cerebellum and long-term potentiation in the hippocampus. It is also involved in the system of NMDA receptors, neurotoxicity, ischemic damage, epilepsy, neurotransmitter's release and sensory system. In this article, we review these phenomena relating NO in the central nervous system with a recent progress in the research of NO.