Abstract
The aim of this study was to investigate the effects of milrinone (MLN) on lung water and hemodynamics in dogs with oleic acid induced lung edema. Extravascular lung water volume (EVLWV) was measured as an index of lung water using a themo/sodium double indicator method. After baseline measurements, 0.08ml/kg of oleic acid was injected into the caval vein. Twelve mongrel dogs were divided into the following two groups; MLN group and control group (C). In the MLN group, 100μg/kg of MLN was administrated by bolus injection followed by infusion at 1.0μg/kg min. The same volume of saline was infused in to the C group. Values were again obtained at 30, 60 120, and 180 minutes after the start of MLN. EVLWV was significantly increased by oleic acid and was significantly reduced in the MLN group compared to the C group. Hypoxemia was improved by MLN. Pulmonary vascular resistance in the MLN group was significantly lower than that in the C group.
